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Epigenetics and Early Abuse
"How Do You Feel About Your Mother?": Epigenetics of Early Experience
Severe childhood abuse is linked to altered expression of a glucocorticoid receptor gene in suicide completers. Freud asserted that character is destiny. Neurobiologists might instead say that genes are destiny. Researchers in a Canadian autopsy study now help us understand how early experience permanently modifies genetic expression in systems that determine our responses to the world around us." Reference: McGowan PO et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009 Mar; 12:342. Hyman SE. How adversity gets under the skin. Nat Neurosci 2009 Mar; 12:241. Medline: http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract |
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